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Does it buy initial test samples in stores or are they provided by the manufacturer? Purchased in stores. Provided by the manufacturer. Provided by the manufacturer. Provided by the manufacturer.
How often does it retest or spot-check? Once per year using samples purchased in stores. Once per year using samples provided by manufacturer and occasionally purchased in stores. One to six times per year using samples purchased in stores. Twice per year using samples purchased in stores.
How much do manufacturers pay to have each product certified? $3,000 to $5,000 per product. $3,000 to $5,000 per product plus an audit fee of about $13,000. $3,000 to $15,000 per product plus an initial audit fee of $15,000 and a label fee of 1 cent per bottle. $2,000 to $8,000 per product plus an audit fee of $4,000 to $7,000.
Are there products it won’t test? Products containing ingredients known to be unsafe. Products marketed for weight loss or sexual enhancement. Products known to contain unsafe ingredients and those marketed for erectile dysfunction, weight loss, or sports. Products containing ingredients known to be unsafe or those not recognized as dietary ingredients by the FDA.
FeaturesBenefits
Rounded-Edge Tread Pattern-softens the contact between individual tread blocks and the ground to combat uneven wear. Dual Interlocking Pyramid Sipes-maintain tread block rigidity for improved tire wear and excellent all-weather traction. Special Compound Technology-contributes to long, even wear through the integration of silica molecules.Long TreadLife
3-Ply Casing-construction for LRE fitments handles heavy loads at highway speeds and delivers outstanding durability. Aggressive Sidewall Protectors-fight off sidewall cuts and abrasions and increase off-road bite.Durability
Dual Interlocking Pyramid Sipes-maintain tread block rigidity for improved tire wear and excellent all-weather traction.All-Season Traction
Multi-Stepped Grooves-increase surface area of the tread for greater traction in dirt or loose gravel. Large Tread Blocks-mean more stability at highway speeds and enhanced handling with less noise.Handling
Rounded-Edge Tread Pattern-softens the contact between individual tread blocks and the ground to reduce noise.Quieter Ride
В Modality (device)В ParameterВ AdvantagesВ DisadvantagesВ 
Regional stiffnessВ DopplerВ cfPWVaВ 
  • Inexpensive, portable

  • Can assess other cardiac and arterial features, e.g. LV hypertrophy, strain

  • Does not require a specific device

  • Faster than applanation tonometry

  • Identification of anatomical landmarks aids repeatability of measurement position

  • Can detect occlusive/atherosclerotic lesions that may affect PWV

В 
  • Operator-dependent skill

  • Sites of measurement limited by acoustic window

  • Lacks versatility for anatomical variations

  • Method of distance measurement overestimates distance

  • Calculation of cfPWV includes iliac and femoral arteries and excludes ascending aorta

In addition:
  • Transit time is determined through visual assessment using digital calipers, limited by temporal resolution

В 
Mechano- transducer (Complior)В cfPWVВ 
  • Similar to Doppler

In addition:
  • Automated device

  • Simultaneous measurements

В 
  • Similar to Doppler

In addition:
  • Variations in transit time algorithms used

  • Underestimates PWV compared with applanation tonometry

  • Cannot provide local wall assessment, where aortic condition may vary

В 
Applanation tonometry (SpyghmoCor)В cfPWVВ 
  • Inexpensive, portable

В 
  • Similar to Doppler

In addition:
  • Two consecutive recordings needed, heart rate variability may cause confounding

  • Local wall assessment not possible

В 
Local stiffnessВ CMRВ aPWV and ADВ 
  • Local and regional assessment of aorta possible

  • Relatively operator independent

  • Full visualization of the entire vessel

  • Imaging planes can be precisely placed with good repeatability

  • Greater spatial and temporal resolution (especially 3Tesla CMR) to study the temporal shift over smaller distances

  • Measurement not affected by anatomical variations, peripheral vascular disease or problems with using probes to detect waveforms

  • Other aspects of cardiac and arterial function can be assessed, e.g. strain and deformation

В 
  • Focal measurement may be prone to sampling error

  • Image analysis can be time-consuming and user dependent

  • Expensive

  • Longer examination time than other methods

  • Not possible with patients with metal implants, or with claustrophobia

  • PP is usually determined non-invasively and peripherally as it is more feasible than invasive measurement

В 

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