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Size
В Modality (device)В ParameterВ AdvantagesВ DisadvantagesВ 
Regional stiffnessВ DopplerВ cfPWVaВ 
  • Inexpensive, portable

  • Can assess other cardiac and arterial features, e.g. LV hypertrophy, strain

  • Does not require a specific device

  • Faster than applanation tonometry

  • Identification of anatomical landmarks aids repeatability of measurement position

  • Can detect occlusive/atherosclerotic lesions that may affect PWV

В 
  • Operator-dependent skill

  • Sites of measurement limited by acoustic window

  • Lacks versatility for anatomical variations

  • Method of distance measurement overestimates distance

  • Calculation of cfPWV includes iliac and femoral arteries and excludes ascending aorta

In addition:
  • Transit time is determined through visual assessment using digital calipers, limited by temporal resolution

В 
Mechano- transducer (Complior)В cfPWVВ 
  • Similar to Doppler

In addition:
  • Automated device

  • Simultaneous measurements

В 
  • Similar to Doppler

In addition:
  • Variations in transit time algorithms used

  • Underestimates PWV compared with applanation tonometry

  • Cannot provide local wall assessment, where aortic condition may vary

В 
Applanation tonometry (SpyghmoCor)В cfPWVВ 
  • Inexpensive, portable

В 
  • Similar to Doppler

In addition:
  • Two consecutive recordings needed, heart rate variability may cause confounding

  • Local wall assessment not possible

В 
Local stiffnessВ CMRВ aPWV and ADВ 
  • Local and regional assessment of aorta possible

  • Relatively operator independent

  • Full visualization of the entire vessel

  • Imaging planes can be precisely placed with good repeatability

  • Greater spatial and temporal resolution (especially 3Tesla CMR) to study the temporal shift over smaller distances

  • Measurement not affected by anatomical variations, peripheral vascular disease or problems with using probes to detect waveforms

  • Other aspects of cardiac and arterial function can be assessed, e.g. strain and deformation

В 
  • Focal measurement may be prone to sampling error

  • Image analysis can be time-consuming and user dependent

  • Expensive

  • Longer examination time than other methods

  • Not possible with patients with metal implants, or with claustrophobia

  • PP is usually determined non-invasively and peripherally as it is more feasible than invasive measurement

В 
StudyDrugSubjectsDesignResults
Gordon et al, 199317ClomipramineN = 305 weeksClomipramine > PLA
Age = 6 - 23CrossoverClomipramine > DMI
Dx = AUT19/28 (68%) responders
Remington et al, 200118ClomipramineN = 367 weeksClomipramine > PLA
HaloperidolAge = 10 - 36CrossoverClomipramine > Haloperidol
Dx = AUT
Sugie et al, 200521FluvoxamineN = 1812 weeksFluvoxamine 5/18 (28%) responders
Age = 3 - 8Crossover
Dx = AUT
McDougle et al, 199624FluvoxamineN = 3012 weeksFluvoxamine > PLA
Age = 18 - 53Parallel groups8/15 (53 %) responders
Dx = AUT
Hollander et aI, 200526FluoxetineN = 458 weeksFluoxetine > PLA repetitive behavior
Age = 5-16Crossover
Dx = AUT, ASP
Hollander et al, 201234FluoxetineN = 3712 weeksFluoxetine > PLA
Age = 18 - 60Parallel groups7/20 (35 %) responders
Dx = AUT
King et al, 200941CitalopramN = 14912 weeksCitalopram = PLA
Age = 5 -17Parallel groups
Dx = AUT
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xxx, The creature is some sixteen feet in length, while its horn averages five feet, though some exceed ten, and even attain to fifteen feet.

xxx, The creature is some sixteen feet in length, while its horn averages five feet, though some exceed ten, and even attain to fifteen feet.


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Xvideos, But Philip could not conceal from himself that the other clerks, ill-paid and uncouth, were more useful than himself. Fling Paris back into the distance, then, exchanging it for endless avenues and cross-avenues of wintry trees! And, when next beheld, let it be some leagues away, with the Gate of the Star a white speck glittering in the sun, and the city a mere mound in a plain--two dark square towers rising out of it, and light and shadow descending on it aslant, like the angels in Jacob's dream! Sir xvideo xx 227f is generally in a complacent state, and rarely bored.



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